El picante posee alcaloides llamados capsaicinoides que provoca irritación en los mamíferos, produciendo una fuerte sensación de ardor en la boca. Cuando sucede esto, nuestra conducta natural es beber bastante agua fría para aplacar el ardor, pero hacer esto es totalmente inútil ya que no se está generando calor real y porque los aceites de la capsina son insolubles en agua.
Para neutralizar el ardor en la boca, el método más eficiente es beber leche ya que contiene alto contenido de grasa. La caseína de la leche envuelve la molécula de capsina, tornándola ineficaz.
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